{"id":23510,"date":"2020-10-22T15:40:02","date_gmt":"2020-10-22T13:40:02","guid":{"rendered":"https:\/\/imagineformargo.org\/?p=23510"},"modified":"2024-05-13T15:01:32","modified_gmt":"2024-05-13T13:01:32","slug":"seludex-trial","status":"publish","type":"post","link":"https:\/\/imagineformargo.org\/en\/seludex-trial\/","title":{"rendered":"SELUDEX trial"},"content":{"rendered":"<p><strong><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-11664 alignleft\" src=\"https:\/\/imagineformargo.org\/wp-content\/uploads\/RECHERCHE.png\" alt=\"RECHERCHE\" width=\"200\" height=\"200\" srcset=\"https:\/\/imagineformargo.org\/wp-content\/uploads\/RECHERCHE.png 2421w, https:\/\/imagineformargo.org\/wp-content\/uploads\/RECHERCHE-768x768.png 768w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><\/strong>EVALUATION OF A NEW TREATMENT FOR ACUTE LYMPHOBLASTIC LEUKEMIA, THE MOST COMMON PEDIATRIC CANCER<\/p>\n<p><em>This trial was co-funded by the Children Without Cancer City 2018 race.<\/em><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><strong>About Childhood Leukemias<\/strong><\/p>\n<p>Leukemia in children shares similarities with adult leukemia but may present certain differences. Acute leukemia is a type of cancer characterized by the spread of cancerous cells originating from the bone marrow stem cells. These cells proliferate uncontrollably, invade the bone marrow, enter the bloodstream, and can thus invade the entire body. This proliferation hampers the production of all blood cells (white and red blood cells, platelets). In 2023, this disease is the most common cancer in children, accounting for approximately 30% of pediatric cancer cases.<\/p>\n<p>The two main types in children are acute lymphoblastic leukemia (80% of cases) and acute myeloid leukemia. The exact causes of leukemia in children are not always clearly defined, but it is believed that they may be linked to genetic, environmental factors, or a combination of certain events occurring at the bone marrow stem cell level.<\/p>\n<p>Learn more about leukemias: [<a href=\"https:\/\/imagineformargo.org\/quest-ce-quune-leucemie\/\" target=\"_blank\" rel=\"noopener\">link<\/a>]<\/p>\n<p>&nbsp;<\/p>\n<p><strong>About the SELUDEX Project<\/strong><\/p>\n<p>SELUDEX is an international phase I\/II therapeutic trial focusing on relapsed or therapeutically failed acute lymphoblastic leukemias. It is the most common pediatric cancer, affecting more than one child per day in France. The trial proposes a combination of Selumetinib, a new MEK inhibitor (targeted therapy), with dexamethasone for the treatment of leukemias with a RAS mutation.<\/p>\n<p>This trial is unique in that it includes both children and adults and has been recently published.<\/p>\n<p>Although this trial did not succeed in including all patients, it provided initial solid indications of the potential of this therapeutic combination. However, during this trial, CAR T-cell therapy was approved for these forms of relapsed or refractory leukemias. Nevertheless, the therapeutic combination developed in this trial could be an interesting solution while patients await their CAR T-cell therapy.<\/p>\n<p><em>This project was funded through donations collected during the 2018 Children Without Cancer race.<\/em><\/p>\n<p>&nbsp;<\/p>\n<p><strong>Summary of the Trial<\/strong><\/p>\n<p><strong>Promoter:<\/strong> University of Birmingham<\/p>\n<p><strong>Principal Investigator:<\/strong> Dr. Tobia Menne<\/p>\n<p><strong>Program Duration:<\/strong> 2018 \u2013 2022<\/p>\n<p><strong>Recruitment:<\/strong> 12 patients were recruited<\/p>\n<p><strong>Countries involved:<\/strong> United Kingdom, France, Denmark, Ireland, Netherlands, Italy<\/p>\n<p><strong>Funding from Imagine for Margo:<\/strong> \u20ac90,000<\/p>\n<p><strong>Other co-funder:<\/strong> Cancer Research UK<\/p>\n<p>Publication: <a href=\"https:\/\/bmjopen.bmj.com\/content\/12\/3\/e059872#T1\">Selumetinib in combination with dexamethasone for the treatment of relapsed\/refractory RAS-pathway mutated paediatric and adult acute lymphoblastic leukaemia (SeluDex): study protocol for an international, parallel-group, dose-finding with expansion phas\u2026 | BMJ Open<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>EVALUATION OF A NEW TREATMENT FOR ACUTE LYMPHOBLASTIC LEUKEMIA, THE MOST COMMON PEDIATRIC CANCER This trial was co-funded by the Children Without Cancer City 2018 race. &nbsp; &nbsp; &nbsp; About Childhood Leukemias Leukemia in children shares similarities with adult leukemia but may present certain differences. Acute leukemia is a type of cancer characterized by the [&hellip;]<\/p>\n","protected":false},"author":12,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[210,160],"tags":[],"class_list":["post-23510","post","type-post","status-publish","format-standard","hentry","category-exclusion-en","category-research"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>SELUDEX trial - Imagine for Margo<\/title>\n<meta name=\"description\" content=\"SELUDEX is an international Phase I \/ II treatment trial in acute lymphoblastic leukemia in relapsing or treatment failure.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/imagineformargo.org\/en\/seludex-trial\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"SELUDEX trial - Imagine for Margo\" \/>\n<meta property=\"og:description\" content=\"SELUDEX is an international Phase I \/ II treatment trial in acute lymphoblastic leukemia in relapsing or treatment failure.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/imagineformargo.org\/en\/seludex-trial\/\" \/>\n<meta property=\"og:site_name\" content=\"Imagine for Margo\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/imagine.for.margo\/\" \/>\n<meta property=\"article:published_time\" content=\"2020-10-22T13:40:02+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-05-13T13:01:32+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/imagineformargo.org\/wp-content\/uploads\/RECHERCHE.png\" \/>\n<meta name=\"author\" content=\"Eva Denjean\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@ImagineforMargo\" \/>\n<meta name=\"twitter:site\" content=\"@ImagineforMargo\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Eva Denjean\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/imagineformargo.org\/en\/seludex-trial\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/imagineformargo.org\/en\/seludex-trial\/\"},\"author\":{\"name\":\"Eva Denjean\",\"@id\":\"https:\/\/imagineformargo.org\/#\/schema\/person\/8efbeaf43525684a641123955b09bf5f\"},\"headline\":\"SELUDEX trial\",\"datePublished\":\"2020-10-22T13:40:02+00:00\",\"dateModified\":\"2024-05-13T13:01:32+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/imagineformargo.org\/en\/seludex-trial\/\"},\"wordCount\":401,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/imagineformargo.org\/#organization\"},\"image\":{\"@id\":\"https:\/\/imagineformargo.org\/en\/seludex-trial\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/imagineformargo.org\/wp-content\/uploads\/RECHERCHE.png\",\"articleSection\":[\"(exclusion)\",\"Research\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/imagineformargo.org\/en\/seludex-trial\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/imagineformargo.org\/en\/seludex-trial\/\",\"url\":\"https:\/\/imagineformargo.org\/en\/seludex-trial\/\",\"name\":\"SELUDEX trial - 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