{"id":31487,"date":"2024-08-07T13:32:07","date_gmt":"2024-08-07T11:32:07","guid":{"rendered":"https:\/\/imagineformargo.org\/?p=31487"},"modified":"2024-08-07T13:32:07","modified_gmt":"2024-08-07T11:32:07","slug":"cobiorb-a-research-program-to-optimize-treatments-for-childhood-retinoblastoma","status":"publish","type":"post","link":"https:\/\/imagineformargo.org\/en\/cobiorb-a-research-program-to-optimize-treatments-for-childhood-retinoblastoma\/","title":{"rendered":"CoBioRB: a research program to optimize treatments for childhood retinoblastoma"},"content":{"rendered":"<p style=\"text-align: left;\">CoBioRB is a research program led by Prof. Petra Ketteler to identify biomarkers for optimizing treatment of childhood retinoblastoma.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-31882 aligncenter\" src=\"https:\/\/imagineformargo.org\/wp-content\/uploads\/2024\/07\/happy-child-next-to-a-doctor-in-hospital-ward-2023-11-27-05-19-24-utc-1000x665.jpg\" alt=\"Retinoblastome\" width=\"1000\" height=\"665\" srcset=\"https:\/\/imagineformargo.org\/wp-content\/uploads\/2024\/07\/happy-child-next-to-a-doctor-in-hospital-ward-2023-11-27-05-19-24-utc-1000x665.jpg 1000w, https:\/\/imagineformargo.org\/wp-content\/uploads\/2024\/07\/happy-child-next-to-a-doctor-in-hospital-ward-2023-11-27-05-19-24-utc-1440x958.jpg 1440w, https:\/\/imagineformargo.org\/wp-content\/uploads\/2024\/07\/happy-child-next-to-a-doctor-in-hospital-ward-2023-11-27-05-19-24-utc-768x511.jpg 768w, https:\/\/imagineformargo.org\/wp-content\/uploads\/2024\/07\/happy-child-next-to-a-doctor-in-hospital-ward-2023-11-27-05-19-24-utc-1536x1022.jpg 1536w, https:\/\/imagineformargo.org\/wp-content\/uploads\/2024\/07\/happy-child-next-to-a-doctor-in-hospital-ward-2023-11-27-05-19-24-utc-2048x1363.jpg 2048w, https:\/\/imagineformargo.org\/wp-content\/uploads\/2024\/07\/happy-child-next-to-a-doctor-in-hospital-ward-2023-11-27-05-19-24-utc-150x100.jpg 150w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><\/p>\n<h2><strong>About Childhood Retinoblastomas<\/strong><\/h2>\n<p>Retinoblastoma is a <a href=\"https:\/\/imagineformargo.org\/en\/what-is-retinoblastoma\/\">malignant tumor<\/a> that develops in the retina, the light-sensitive tissue layer at the back of the eye. This tumor originates from immature retinal cells called &#8220;developing retinal cells.&#8221;<\/p>\n<p>Retinoblastoma is a cancer primarily affecting young children, typically before the age of 5 (95% of cases). Approximately 50 to 60 new cases are estimated each year in France (about 2% of pediatric cancers).<\/p>\n<p style=\"text-align: center;\"><div class=\"media--video-embed\"><iframe loading=\"lazy\" title=\"YouTube video player\" src=\"https:\/\/www.youtube.com\/embed\/fk-i3sFMajc?si=w-RpZq9u7v1ncZi7\" width=\"560\" height=\"315\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/div><\/p>\n<p>Treatment for retinoblastoma depends on the size, location, and spread of the tumor. Treatment options may include surgery, radiotherapy, chemotherapy, or a combination of these methods. Prognosis for children with retinoblastoma also depends on the extent of the disease and how quickly it is diagnosed and treated.<\/p>\n<h2><strong>About CoBioRB<\/strong><\/h2>\n<p>CoBioRB is a collaborative study aimed at identifying biomarkers that will help tailor stratified treatment for children with retinoblastoma. Specifically, the genetic and genomic characteristics of retinoblastoma subtypes will be characterized to identify biomarkers for tumors with high or low metastatic risk. In the second phase, the international team leading this project will quantify the amount of circulating tumor DNA (ctDNA) in biological fluids (blood) of retinoblastoma patients. They will investigate the hypothesis that ctDNA quantity correlates with tumor burden and risk of metastasis. The study will collect tumor tissues and samples of blood, cerebrospinal fluid, and aqueous humor from 35 patients across 6 centers. The identified biomarkers could help identify patients at risk of metastasis to mitigate late treatment effects in others. CoBioRB forms the basis of a pan-European clinical trial &#8220;EURBG2&#8221; on biomarkers for risk stratification of adjuvant treatment for retinoblastoma.<\/p>\n<h2><strong>Project Progress<\/strong><\/h2>\n<p>The project has made good progress, with genetic analyses conducted on 156 tumor samples to develop the first phase of the project.<\/p>\n<h3><strong>Summary of the CoBioRB Project<\/strong><\/h3>\n<ul>\n<li>Lead Investigators: Prof. Petra Ketteler<\/li>\n<li>Program Duration: January 2023 &#8211; January 2025<\/li>\n<li>Countries Involved: Netherlands, France, Spain, UK, Germany, Switzerland<\/li>\n<li><a href=\"https:\/\/fightkidscancer.eu\/\">Fight Kids Cancer<\/a> Funding: \u20ac500,000, including <a href=\"https:\/\/imagineformargo.org\/en\/\">Imagine for Margo<\/a> funding: \u20ac500,000<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>CoBioRB is a research program led by Prof. Petra Ketteler to identify biomarkers for optimizing treatment of childhood retinoblastoma. About Childhood Retinoblastomas Retinoblastoma is a malignant tumor that develops in the retina, the light-sensitive tissue layer at the back of the eye. This tumor originates from immature retinal cells called &#8220;developing retinal cells.&#8221; Retinoblastoma is [&hellip;]<\/p>\n","protected":false},"author":20,"featured_media":31883,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[160],"tags":[],"class_list":["post-31487","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>CoBioRB: a research program to optimize treatments for childhood retinoblastoma - Imagine for Margo<\/title>\n<meta name=\"description\" content=\"Discover Prof. Petra Ketteler&#039;s retinoblastoma program funded by Imagine for Margo as part of Fight Kids Cancer.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, 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