Research
Study of Predisposition to Therapeutic Resistance in Osteosarcomas
Study of Predisposition to Therapeutic Resistance in Osteosarcomas
Background of the Project Osteosarcoma is the most common primary bone tumor affecting children and young adults (incidence peak between 15 and 19 years old). The current treatment for this cancer involves tumor removal, combined with polychemotherapy. Unfortunately, a lack of response to antitumor drugs is often observed, promoting the development of metastases and leading […]Development of 3D Organoids as Tools for Characterizing Mechanisms Underlying Resistance to Cell Death in Pediatric Ependymomas
Development of 3D Organoids as Tools for Characterizing Mechanisms Underlying Resistance to Cell Death in Pediatric Ependymomas
Ependymoma is one of the most common malignant brain tumors in children and adolescents. It develops in the ependymal tissue, which lines the brain’s ventricles and the central canal of the spinal cord. These tumors can be found in various locations, including different brain ventricles (most commonly) or along the central canal of the spinal […]Multicentric study combining arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) for patients with acute promyelocytic leukemia
Multicentric study combining arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) for patients with acute promyelocytic leukemia
Childhood Leukemias Leukemia in children is similar to that in adults but may have some particularities. Acute leukemia is a type of cancer characterized by the dissemination of cancerous cells originating from the bone marrow stem cells. They multiply chaotically, invade the bone marrow, enter the bloodstream, and can thus invade the entire body. This […]Tag-N-Trak, molecular characterization of tumors with NTRK transcripts
Tag-N-Trak, molecular characterization of tumors with NTRK transcripts
Fusion Proteins Enhance Cancer Detection In recent years, research laboratories have discovered that certain tumors contain a specific and abnormal protein resulting from the aberrant fusion of two chromosome fragments. This abnormal form, called a “fusion transcript,” is most often responsible for cancer development. Until now, these fusion transcripts have primarily served to better diagnose […]Innovative 3D Technologies in Pediatric Renal Tumors
Innovative 3D Technologies in Pediatric Renal Tumors
Kidney Cancers in Children Approximately one hundred children and adolescents (aged 0 to 19) are diagnosed with renal tumors each year, accounting for 7% of pediatric cancers. Pediatric renal tumors include Wilms tumors (WT, the most common form), renal cell carcinoma, clear cell sarcoma of the kidney, mesoblastic nephroma, rhabdoid tumors, and other rarer cancers. […]Evaluation of Residual Disease by Next-Generation Sequencing (NGS) in Childhood AML
Evaluation of Residual Disease by Next-Generation Sequencing (NGS) in Childhood AML
Acute Myeloid Leukemias in Children Acute myeloid leukemia (AML) is a cancer of the blood and bone marrow. AML is the second most common leukemia in children, after acute lymphoblastic leukemia (ALL). Each year, approximately 80 children in France are diagnosed with AML. It is most frequent during the first two years of life and […]What is an osteosarcoma?
What is an osteosarcoma?
Osteosarcoma is the most common malignant bone tumor in adolescents and young adults (100 to 150 new patients per year in France). The majority of these osteosarcomas (70%) occur in young people aged 10 to 25 years, and it affects boys more frequently (1 girl affected for every 1.4 boys). Localized osteosarcomas are limited to […]Sample Collection to Establish a Biological and Genomic Research Network on Osteosarcomas in France
