Targeting DNA Repair in H3.3 Mutant High-Grade Pediatric Gliomas
Targeting DNA Repair in H3.3 Mutant High-Grade Pediatric Gliomas
High-Grade Gliomas in Children High-grade gliomas are the most common malignant tumors in children and adolescents. Our understanding of these cancers, particularly gained during the BIOMEDE trial led by Dr. Jacques Grill, has led to better defining and understanding these diseases. Now that we know that malignant gliomas in children and adults are not alike, […]
Assessment of the Toxicity of Intravitreal Carboplatin Injections in the Treatment of Retinoblastoma
Assessment of the Toxicity of Intravitreal Carboplatin Injections in the Treatment of Retinoblastoma
Childhood Retinoblastomas Retinoblastoma is a malignant tumor that develops in the retina, the layer of light-sensitive tissue at the back of the eye. This tumor arises from immature retinal cells called “developing retinal cells.” Retinoblastoma is a cancer that mainly affects young children, typically before the age of 5 (95% of cases). Estimates suggest that […]
Targeting Pediatric Brain Tumors with O-Acetyl-GD2-specific CAR T Lymphocytes
Targeting Pediatric Brain Tumors with O-Acetyl-GD2-specific CAR T Lymphocytes
Childhood Brain Cancers Brain tumors are the most common solid tumors in children. The annual estimated number of new cases is about 30 per million for all childhood brain tumors. Gliomas encompass tumors of the central nervous system, which differ based on the brain’s original cell types (astrocytes or oligodendrocytes or both) and their aggressiveness […]
Study of Predisposition to Therapeutic Resistance in Osteosarcomas
Study of Predisposition to Therapeutic Resistance in Osteosarcomas
Background of the Project Osteosarcoma is the most common primary bone tumor affecting children and young adults (incidence peak between 15 and 19 years old). The current treatment for this cancer involves tumor removal, combined with polychemotherapy. Unfortunately, a lack of response to antitumor drugs is often observed, promoting the development of metastases and leading […]
Development of 3D Organoids as Tools for Characterizing Mechanisms Underlying Resistance to Cell Death in Pediatric Ependymomas
Development of 3D Organoids as Tools for Characterizing Mechanisms Underlying Resistance to Cell Death in Pediatric Ependymomas
Ependymoma is one of the most common malignant brain tumors in children and adolescents. It develops in the ependymal tissue, which lines the brain’s ventricles and the central canal of the spinal cord. These tumors can be found in various locations, including different brain ventricles (most commonly) or along the central canal of the spinal […]
Multicentric study combining arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) for patients with acute promyelocytic leukemia
Multicentric study combining arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) for patients with acute promyelocytic leukemia
Childhood Leukemias Leukemia in children is similar to that in adults but may have some particularities. Acute leukemia is a type of cancer characterized by the dissemination of cancerous cells originating from the bone marrow stem cells. They multiply chaotically, invade the bone marrow, enter the bloodstream, and can thus invade the entire body. This […]
Tag-N-Trak, molecular characterization of tumors with NTRK transcripts
Tag-N-Trak, molecular characterization of tumors with NTRK transcripts
Fusion Proteins Enhance Cancer Detection In recent years, research laboratories have discovered that certain tumors contain a specific and abnormal protein resulting from the aberrant fusion of two chromosome fragments. This abnormal form, called a “fusion transcript,” is most often responsible for cancer development. Until now, these fusion transcripts have primarily served to better diagnose […]
Innovative 3D Technologies in Pediatric Renal Tumors
Innovative 3D Technologies in Pediatric Renal Tumors
Kidney Cancers in Children Approximately one hundred children and adolescents (aged 0 to 19) are diagnosed with renal tumors each year, accounting for 7% of pediatric cancers. Pediatric renal tumors include Wilms tumors (WT, the most common form), renal cell carcinoma, clear cell sarcoma of the kidney, mesoblastic nephroma, rhabdoid tumors, and other rarer cancers. […]
