What is a rhabdomyosarcoma?
What is a rhabdomyosarcoma?
Rhabdomyosarcoma (RMS) is the most common soft tissue cancer (approximately 60%) in children and adolescents (5% of all pediatric solid tumors). However, it remains a rare cancer with about a hundred cases recorded in France per year. It occurs at all ages with a peak incidence between 2 and 5 years. RMS develops from skeletal […]
Role of Calcium Conductances in the Development of Pediatric Sarcomas
Role of Calcium Conductances in the Development of Pediatric Sarcomas
Childhood Sarcomas After blood cancers and brain tumors, sarcomas are the most common pediatric tumors. Among these, we distinguish soft tissue sarcomas including rhabdomyosarcomas (RMS, the most common) and bone sarcomas including Ewing sarcomas (ES, the second most common after osteosarcomas). In pediatrics, sarcomas develop at any age and in any part of the body, […]
Targeting DNA Repair in H3.3 Mutant High-Grade Pediatric Gliomas
Targeting DNA Repair in H3.3 Mutant High-Grade Pediatric Gliomas
High-Grade Gliomas in Children High-grade gliomas are the most common malignant tumors in children and adolescents. Our understanding of these cancers, particularly gained during the BIOMEDE trial led by Dr. Jacques Grill, has led to better defining and understanding these diseases. Now that we know that malignant gliomas in children and adults are not alike, […]
Assessment of the Toxicity of Intravitreal Carboplatin Injections in the Treatment of Retinoblastoma
Assessment of the Toxicity of Intravitreal Carboplatin Injections in the Treatment of Retinoblastoma
Childhood Retinoblastomas Retinoblastoma is a malignant tumor that develops in the retina, the layer of light-sensitive tissue at the back of the eye. This tumor arises from immature retinal cells called “developing retinal cells.” Retinoblastoma is a cancer that mainly affects young children, typically before the age of 5 (95% of cases). Estimates suggest that […]
Targeting Pediatric Brain Tumors with O-Acetyl-GD2-specific CAR T Lymphocytes
Targeting Pediatric Brain Tumors with O-Acetyl-GD2-specific CAR T Lymphocytes
Childhood Brain Cancers Brain tumors are the most common solid tumors in children. The annual estimated number of new cases is about 30 per million for all childhood brain tumors. Gliomas encompass tumors of the central nervous system, which differ based on the brain’s original cell types (astrocytes or oligodendrocytes or both) and their aggressiveness […]
Study of Predisposition to Therapeutic Resistance in Osteosarcomas
Study of Predisposition to Therapeutic Resistance in Osteosarcomas
Background of the Project Osteosarcoma is the most common primary bone tumor affecting children and young adults (incidence peak between 15 and 19 years old). The current treatment for this cancer involves tumor removal, combined with polychemotherapy. Unfortunately, a lack of response to antitumor drugs is often observed, promoting the development of metastases and leading […]
Development of 3D Organoids as Tools for Characterizing Mechanisms Underlying Resistance to Cell Death in Pediatric Ependymomas
Development of 3D Organoids as Tools for Characterizing Mechanisms Underlying Resistance to Cell Death in Pediatric Ependymomas
Ependymoma is one of the most common malignant brain tumors in children and adolescents. It develops in the ependymal tissue, which lines the brain’s ventricles and the central canal of the spinal cord. These tumors can be found in various locations, including different brain ventricles (most commonly) or along the central canal of the spinal […]
Multicentric study combining arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) for patients with acute promyelocytic leukemia
Multicentric study combining arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) for patients with acute promyelocytic leukemia
Childhood Leukemias Leukemia in children is similar to that in adults but may have some particularities. Acute leukemia is a type of cancer characterized by the dissemination of cancerous cells originating from the bone marrow stem cells. They multiply chaotically, invade the bone marrow, enter the bloodstream, and can thus invade the entire body. This […]
