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Multicentric study combining arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) for patients with acute promyelocytic leukemia

Multicentric study combining arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) for patients with acute promyelocytic leukemia

Multicentric study combining arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) for patients with acute promyelocytic leukemia

Childhood Leukemias Leukemia in children is similar to that in adults but may have some particularities. Acute leukemia is a type of cancer characterized by the dissemination of cancerous cells originating from the bone marrow stem cells. They multiply chaotically, invade the bone marrow, enter the bloodstream, and can thus invade the entire body. This […]

Tag-N-Trak, molecular characterization of tumors with NTRK transcripts

Tag-N-Trak, molecular characterization of tumors with NTRK transcripts

Tag-N-Trak, molecular characterization of tumors with NTRK transcripts

Fusion Proteins Enhance Cancer Detection In recent years, research laboratories have discovered that certain tumors contain a specific and abnormal protein resulting from the aberrant fusion of two chromosome fragments. This abnormal form, called a “fusion transcript,” is most often responsible for cancer development. Until now, these fusion transcripts have primarily served to better diagnose […]

Innovative 3D Technologies in Pediatric Renal Tumors

Innovative 3D Technologies in Pediatric Renal Tumors

Innovative 3D Technologies in Pediatric Renal Tumors

Kidney Cancers in Children Approximately one hundred children and adolescents (aged 0 to 19) are diagnosed with renal tumors each year, accounting for 7% of pediatric cancers. Pediatric renal tumors include Wilms tumors (WT, the most common form), renal cell carcinoma, clear cell sarcoma of the kidney, mesoblastic nephroma, rhabdoid tumors, and other rarer cancers. […]

Evaluation of Residual Disease by Next-Generation Sequencing (NGS) in Childhood AML

Evaluation of Residual Disease by Next-Generation Sequencing (NGS) in Childhood AML

Evaluation of Residual Disease by Next-Generation Sequencing (NGS) in Childhood AML

Acute Myeloid Leukemias in Children Acute myeloid leukemia (AML) is a cancer of the blood and bone marrow. AML is the second most common leukemia in children, after acute lymphoblastic leukemia (ALL). Each year, approximately 80 children in France are diagnosed with AML. It is most frequent during the first two years of life and […]

What is an osteosarcoma?

What is an osteosarcoma?

What is an osteosarcoma?

Osteosarcoma is the most common malignant bone tumor in adolescents and young adults (100 to 150 new patients per year in France). The majority of these osteosarcomas (70%) occur in young people aged 10 to 25 years, and it affects boys more frequently (1 girl affected for every 1.4 boys). Localized osteosarcomas are limited to […]

Sample Collection to Establish a Biological and Genomic Research Network on Osteosarcomas in France

Sample Collection to Establish a Biological and Genomic Research Network on Osteosarcomas in France

Sample Collection to Establish a Biological and Genomic Research Network on Osteosarcomas in France

Osteosarcomas in Children Osteosarcoma is the most common malignant bone tumor or bone cancer (tumors originating in the bone) in adolescents and young adults. Osteosarcoma affects about 100 to 150 new patients per year in France, occurring in young people aged 10 to 25 years and affects boys more (1 girl affected for every 1.4 […]

Creation of the RELYE network: “REseau des LYmphomes Pédiatriques”

Creation of the RELYE network: “REseau des LYmphomes Pédiatriques”

Creation of the RELYE network: “REseau des LYmphomes Pédiatriques”

Childhood Lymphomas Close to 200 children and adolescents are diagnosed with lymphoma each year in France. These are cancers of the lymphatic system where tumor cells originate from lymphocytes, commonly known as “white blood cells.” There are two main types of lymphomas: Hodgkin lymphomas (HL), which predominantly affect adolescents and adults. Non-Hodgkin lymphomas (NHL), more […]

Study of the clonal evolution of high-risk neuroblastoma under targeted therapy

Study of the clonal evolution of high-risk neuroblastoma under targeted therapy

Study of the clonal evolution of high-risk neuroblastoma under targeted therapy

Children’s Neuroblastomas Neuroblastoma is an extra-cerebral malignant tumor that develops from primitive nerve cells, called neuroblasts, which normally form the body’s nerve cells. This type of solid tumor is one of the most common in children. This cancer originates from the sympathetic nervous system (which prepares the body for intense activity) in the abdomen and […]