Creation of the RELYE network: “REseau des LYmphomes Pédiatriques”
Creation of the RELYE network: “REseau des LYmphomes Pédiatriques”
Childhood Lymphomas Close to 200 children and adolescents are diagnosed with lymphoma each year in France. These are cancers of the lymphatic system where tumor cells originate from lymphocytes, commonly known as “white blood cells.” There are two main types of lymphomas: Hodgkin lymphomas (HL), which predominantly affect adolescents and adults. Non-Hodgkin lymphomas (NHL), more […]
Study of the clonal evolution of high-risk neuroblastoma under targeted therapy
Study of the clonal evolution of high-risk neuroblastoma under targeted therapy
Children’s Neuroblastomas Neuroblastoma is an extra-cerebral malignant tumor that develops from primitive nerve cells, called neuroblasts, which normally form the body’s nerve cells. This type of solid tumor is one of the most common in children. This cancer originates from the sympathetic nervous system (which prepares the body for intense activity) in the abdomen and […]
Identification of New Therapeutic Approaches for Ewing Sarcomas Based on Fusion Protein Destabilization
Identification of New Therapeutic Approaches for Ewing Sarcomas Based on Fusion Protein Destabilization
Pediatric Sarcomas Ewing sarcoma is the second most common malignant bone tumor after osteosarcoma in adolescents and young adults. Ewing sarcoma affects approximately 80 to 100 new patients per year in France. The majority of cases (70%) occur in young people aged 5 to 25 years. However, these tumors can be diagnosed before the age […]
Genetic diagnostic platform for the study of pediatric brain tumors
Genetic diagnostic platform for the study of pediatric brain tumors
Pediatric Brain Cancers Brain tumors are the most common solid tumors in pediatrics. The annual estimated number of new cases is around 30 per million. Gliomas remain the most common central nervous system tumors in children, with high-grade forms being the most difficult to treat. Knowledge gained in recent years, particularly in the molecular classification […]
Preclinical Study of the Effect of the Molecule CEL-001 for the Treatment of High-Risk Neuroblastoma
Preclinical Study of the Effect of the Molecule CEL-001 for the Treatment of High-Risk Neuroblastoma
Neuroblastomas in Children A neuroblastoma is an extracranial malignant tumor that develops from primitive nerve cells, called neuroblasts, which normally form the nerve cells of the body. This type of solid tumor is one of the most common in children. This disease represents 10% of solid tumors in children under 15 years old and mainly […]
Evaluation of Potential Damage to the Brain and Its Vascularization from Flash Proton Therapy
Evaluation of Potential Damage to the Brain and Its Vascularization from Flash Proton Therapy
Proton Therapy in Children Proton therapy is a high-precision radiotherapy method that reduces the exposure of healthy tissues surrounding the tumor, thus lowering radiation toxicity compared to conventional radiotherapy. It is therefore perfectly suited for treating children. About the Project Brain tumors are the most common solid tumors in children and are widely treated with […]
Interest of 3D Modeling in the Surgery of Neuroectodermal Tumors in Children
Interest of 3D Modeling in the Surgery of Neuroectodermal Tumors in Children
The Interest of 3D Modeling in Pediatric Surgery Pediatric genetic, developmental, and oncological diseases have not benefited from advancements in advanced simulation, computer assistance, and automation, especially for surgical interventions. This is unfortunate, particularly because the pediatric population requires special attention due to the specific nature of the pathologies involved (malformations and tumors) and the […]
CoBioRB: a research program to optimize treatments for childhood retinoblastoma
CoBioRB: a research program to optimize treatments for childhood retinoblastoma
CoBioRB is a research program led by Prof. Petra Ketteler to identify biomarkers for optimizing treatment of childhood retinoblastoma. About Childhood Retinoblastomas Retinoblastoma is a malignant tumor that develops in the retina, the light-sensitive tissue layer at the back of the eye. This tumor originates from immature retinal cells called “developing retinal cells.” Retinoblastoma is […]
