TRIAL ON BRAIN TUMORS
Dissecting thePathOgenic mechanisms in central nervous system high-grade neuroepithelial tumors with BCOR-alteratioN (CNS HGNET-BCOR)
Central nervous system high-grade neuroepithelial tumor with BCOR-alteration (CNS HGNET-BCOR) is a recently described tumor entity with distinct molecular characteristics which exhibits high aggressiveness and poor clinical outcome. To date it is not known which biological processes drive this tumor type and no effective treatments exist. The collaborative project POBCORN aims at in-depth investigation of CNS HGNET-BCOR biology with cutting-edge molecular technologies. Thereby, we hope to identify oncogenic driver-events of this tumor as well as potential therapeutic targets. In summary, our project aims at providing first translational guidance on how to treat CNS HGNET-BCOR patients in future clinical trials.
Principal Investigator: Johannes Gojo, MD, PhD, Department of Pediatrics and Adolescent Medicine; Medical University of Vienna
Countries involved: Austria, Germany, the United States
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